About Astellas Gene Therapies

Astellas Gene Therapies is an Astellas Center of Excellence developing genetic medicines for patients with rare, life-threatening diseases. Based on our innovative approach to developing genetic medicines, as well as our industry-leading internal manufacturing capability and expertise, we have become the Astellas Center of Excellence for their newly-created Genetic Regulation Focus Area. We are currently exploring three gene therapy modalities: gene replacement, exon skipping gene therapy, and vectorized RNA knockdown, with plans to expand our focus and geographic reach under Astellas. We are based in San Francisco, with manufacturing and laboratory facilities in South San Francisco and Sanford, North Carolina. For more information, please visit our website: www.astellasgenetherapies.com

About Astellas

Astellas Pharma Inc. is a pharmaceutical company conducting business in more than 70 countries around the world. We are promoting the Focus Area Approach that is designed to identify opportunities for the continuous creation of new drugs to address diseases with high unmet medical needs by focusing on Biology and Modality. Furthermore, we are also looking beyond our foundational Rx focus to create Rx+® healthcare solutions that combine our expertise and knowledge with cutting-edge technology in different fields of external partners. Through these efforts, Astellas stands on the forefront of healthcare change to turn innovative science into value for patients. For more information, please visit our website at https://www.astellas.com/en.

Our Values:

Be BOLD (Find a Way)

Care Deeply – for our patients, each other and our work

#GSD (Get Stuff Done)

What is the catalyst for you in your professional career? Are you ready to be a part of a bold, innovative company, to make a change and to make a difference? Listed below is a current opening for a smart, driven, experienced, and just plain nice individual who wants to join us and be a part of our journey.

The Role

The primary responsibilities of the Biophysical Characterization Research Associate will include performing analytical method development and testing samples using HPLC, capillary electrophoresis and other analytical tools; contributing to design and performing experiments with supervision as needed, for completing tasks within assigned time frames and for maintaining a well-documented record of activities in batch records and lab notebook. The position level will be commensurate with education and experience level. Additionally, the role includes regularly summarizing experiments in lab meetings and assisting in generating reports. This role will be at our South San Francisco location.

Primary Responsibilities

Conducting experiments to characterize adeno associated viral nanoparticles for gene therapy products

Developing and running assays for particle/protein/DNA biophysical assays (SDS-PAGE, DLS, Western Blot, Light Obscuration, RP, SE – HPLC methods, AUC, Capillary Electrophoresis)

Developing additional assays as needed for process development and formulation studies

Developing new characterization tools or following SOPs and running experiments according to guidelines

Assisting in formulation and stability study set up, monitoring and analyzing data using statistical methods

Assisting in writing, reviewing, and editing experimental procedures and reports

Maintaining accurate records of all analytical development activities

Analyzing and determining the applicability of laboratory data to draw conclusions and to make appropriate recommendations

Must Have/Required

Bachelor of Science with 1+ year experience working in a pharmaceutical or biotech company and with the requisite years’ of experience and with the requisite years’ of experience employing the skills listed in the job description (for each level) performing biophysical assays for the characterization of proteins and DNA

Successful experience operating SDS-PAGE, CE, AUC, HPLC or other technologies for protein/DNA based product development

Strong knowledge of Protein and DNA chemistry

Knowledge and proven experience in protein-based product development and characterization

Knowledge and expertise in principles and practice of current Good Manufacturing Practices (cGMP)

Proficient in Microsoft Office to include Excel, PowerPoint, Word

Demonstrated verbal and written skills in technical reports and documents

Positive, professional self-starter with a passion for science

Proven ability to work collaboratively in a team environment as well as being an individual contributor

Models our Core Values: Be Bold: Find a Way, Care Deeply, Get Stuff Done – is experienced as someone who exemplifies the culture we want to create; operates with transparency; is trusted.

May Have/Preferred

Knowledge of protein formulation

Experience with Waters platform

Experience in analytical method development and validation

Benefits:

Medical, Dental and Vision Insurance

Generous Paid Time Off options, including Vacation and Sick time, plus national holidays including year-end shut down

401(k) match and annual company contribution

Company paid life insurance

Annual Corporate Bonus and Quarterly Sales Incentive for eligible positions

Long Term Incentive Plan for eligible positions

Category Gene Therapy Research & Technical Operations

Astellas is committed to equality of opportunity in all aspects of employment.

EOE including Disability/Protected Veterans