Alkermes Overview

Alkermes, Inc. is the U.S. operating company of Alkermes plc, a fully integrated, global biopharmaceutical company that applies its scientific expertise and proprietary technologies to research, develop and commercialize, both with partners and on its own, pharmaceutical products that are designed to address unmet medical needs of patients in major therapeutic areas. Alkermes has a diversified portfolio of marketed products focused on central nervous system disorders such as addiction and schizophrenia and a pipeline of product candidates in the fields of neuroscience and oncology. Headquartered in Dublin, Ireland, Alkermes has a research and development (“R&D”) center in Waltham, Massachusetts; an R&D and manufacturing facility in Athlone, Ireland; and a manufacturing facility in Wilmington, Ohio.

The following position is for Alkermes, Inc.

Job Description

We are seeking an enthusiastic and highly motivated Scientist to join the Modeling and Informatics group within Alkermes R&D.

• Through the innovative use of state-of-the-art structure-based and ligand-based modeling approaches generate testable hypotheses that drive medicinal chemistry and protein design strategies
• As member of drug discovery design teams contribute to the success of small molecule and protein design projects
• Develop drug discovery knowledge and skills beyond the domain of expertise
• Derive information, insight, and knowledge from experimental and in silico data through the development, implementation, and application of AI/ML-driven predictive and generative modeling approaches
• Contribute to the development and implementation of the Modeling & Informatics strategy at Alkermes
• Communicate scientific results effectively internally as well as in external presentations and publications

Education and Experience

• Ph.D. in computational chemistry or a related field with 0-5 years of experience or M.S. with 8+ years of related experience are required; 1-2 years of industry experience is preferred

• Working knowledge of medicinal and organic chemistry and DMPK principles
• An outstanding scientific track record in the area of expertise.
• A demonstrated intimate understanding of 3D protein-ligand interactions applied to molecular design concepts.
• Experience in applying chemoinformatics approaches to solving problems in data mining, implementing new tools, and generating automated workflows using Knime or other workflow tools
• A demonstrated expertise in scientific programming (e.g., Python, Java, C, SVL) with practical application of these skills
• Experience with AI/ML is preferred
• Experience with molecular dynamics simulation techniques is desirable
• Excellent oral and written communication skills and good presentation skills
• Ability to work in a fast-paced, goal-oriented team environment.

Key Tasks

• As an active and innovative member of research teams define modeling objectives and deliver creative solutions driving the discovery of novel small molecules and protein therapeutics through the inventive design and the imaginative use of molecular modeling and informatics technology

• Work closely with medicinal chemists and protein engineers in designing new molecules and provide a framework of predictive models to enable the generation of data driven hypotheses and efficient decision making for the synthesis and advancement of compounds

• Influence the building of a computational chemistry framework that enables the streamlining of in silico workflows and technologies

• Generate automated and modular calculation engines and computational services that enable team members to seamlessly execute project specific modeling workflows for the exploration and capturing of new design ideas

• Propose technology initiatives, and be directly engaged in the development of tools that improve computational chemistry approaches and workflows for small molecule and biologically active protein drug designs and cheminformatics analyses

• Work closely with medicinal chemists and IT specialists to find creative solutions to data management, dissemination, and analysis challenges

• Identify and evaluate new modeling & informatics technology and software available from commercial sources or through external collaboration opportunities

• Participate in new target evaluations through the creative use molecular modeling and chemoinformatics technologies

Alkermes, Inc. is an equal employment opportunity employer and does not discriminate against any applicant because of race, creed, color, age, national origin, ancestry, religion, gender, sexual orientation, gender expression and identity, disability, genetic information, veteran status, military status, application for military service or any other class protected by state or federal law. Alkermes also complies with all work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Alkermes is an E-Verify employer.

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