Required Qualifications:

• Ph.D. in Biomedical Engineering or relevant fields including but not limited to Stem Cell Biology, Quantitative Biology, Mechanical Engineering and Molecular Biology
• Demonstrated track record with first author publications in established societal or field-leading journals and other indicators of productive research
• Successful candidates will be able to independently develop scientific hypotheses based on data and literature and then design experiments to test
• Successful candidates will have excellent communication skills both written and verbal
• Successful candidates will be able to work collaboratively and mentor junior level trainees

The position will seek to address the aims of a currently funded NIH R01 and is available immediately in the Department of Biomedical Engineering at the University
of Minnesota-Twin Cities. In this proposal, we focus on the crucial role of epicardial- myocardial signaling in cardiac morphogenesis and seek to elucidate the signals
that drive these interactions.

During development, the epicardium modulates cardiomyocyte (CM) behavior through biochemical signals and the contribution of
multiple supporting cell types to the heart. Epicardial progenitor cells (EPCs) promote ventricular compaction via induction of CM proliferation, and in vitro
evidence suggests a role for epicardial-derived cells (EPDCs), especially cardiac fibroblasts (CFs), in promoting the structural and functional maturation of CMs. We
hypothesize that these processes occur, in part, through the secretion of growth factors (GFs) and matricellular proteins by EPCs as well as the deposition of critical
and evolving extracellular matrix (ECM) cues by EPDCs. Here we propose to probe these interactions in 3D and identify crucial signaling components that alter human
induced pluripotent stem cell-derived cardiomyocyte (hiPSC-CM) behavior. We will then, for the first time, incorporate a functional epicardial layer into a human,
chambered cardiac muscle pump (hChaMP) model to achieve native pressure- volume dynamics.

There are multiple projects that could be pursued within the overall grant structure. One project will include culture of stem cells and multiple stem cell-derived cardiac cell types, molecular analyses and phenotypic/functional analyses. Another project will involve development of bioreactor systems to house the hChaMPs and promote proper function and scale up.

The Department of Biomedical Engineering (BME) at the University of Minnesota conducts innovative research, offers high-quality education, and has strong connections to the thriving Twin Cities medical device industry.

Our mission

• Conduct pioneering, high-impact research spanning basic science to clinical and technological application.

• Educate the next generation of trailblazers who will define new paths based on fundamental training and emerging knowledge.

• Foster an inclusive community that supports the growth and learning of all members.

• Accelerate and augment impact through our unique proximity to the biomedical industry and adjacent clinical medicine.

Applications must be submitted online. To be considered for this position, please click the Apply button and follow the instructions. You will be given the opportunity to complete an online application for the position and attach a cover letter and resume.

Additional documents may be attached after application by accessing your "My Job Applications" page and uploading documents in the "My Cover Letters and Attachments" section.

To request an accommodation during the application process, please e-mail employ@umn.edu or call (612) 624-UOHR (8647).

The University recognizes and values the importance of diversity and inclusion in enriching the employment experience of its employees and in supporting the academic mission. The University is committed to attracting and retaining employees with varying identities and backgrounds.

The University of Minnesota provides equal access to and opportunity in its programs, facilities, and employment without regard to race, color, creed, religion, national origin, gender, age, marital status, disability, public assistance status, veteran status, sexual orientation, gender identity, or gender expression. To learn more about diversity at the U: http://diversity.umn.edu

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The University of Minnesota, Twin Cities (UMTC)

The University of Minnesota, Twin Cities (UMTC), is among the largest public research universities in the country, offering undergraduate, graduate, and professional students a multitude of opportunities for study and research. Located at the heart of one of the nation's most vibrant, diverse metropolitan communities, students on the campuses in Minneapolis and St. Paul benefit from extensive partnerships with world-renowned health centers, international corporations, government agencies, and arts, nonprofit, and public service organizations.