What You Will Contribute To Altos

The Altos Institute of Medicine will capture knowledge generated about cell health and programming and develop transformative medicines. We are seeking a highly experienced biotech/pharma executive to be one of the founding senior leaders of the Altos Institute of Medicine. The successful candidate is a demonstrated strategic leader who builds high-performing teams and drives innovation to develop new medicines. Critical to this position is engaging actively with the research efforts in the three Altos Institutes of Science, and demonstrating highly collaborative partnerships with the Institute Directors and Principal Investigator teams.

As a founding member of the Non-Clinical team, the leader will be instrumental in building out the non-clinical function and will be instrumental in setting up the strategy and operations for our future portfolio.

The selected candidate will provide portfolio-wide oversight of non-clinical safety programs from candidate nomination (or earlier, as needed) through clinical development, and scientific and regulatory support for pharmacology/toxicology sections of regulatory submissions.

They will have demonstrated expertise in non-clinical safety and a broad understanding of toxicology/pathology, ADME, bioanalytical, regulatory, and clinical pharmacology for research programs and early clinical programs and will be called upon to make significant contributions to therapeutic strategy and execution across the organization.

As a member of the Institute of Medicine Leadership Team, you will play a key role in developing, shaping and implementing the overall technical strategy of Altos. The VP/SVP will partner and work closely with numerous external and internal stakeholders across Altos, especially our Institutes of Science and Regulatory leaders operating in a global capacity throughout all Altos sites.

• Accountable for non-clinical study strategy and execution across the Altos research and clinical portfolio, including experimental approach, data package, and regulatory content to advance our platform technologies and diverse pipeline of development candidates
• Develop an enterprise view of the non-clinical contributions to Altos' technologies and pipeline, identifying opportunities to increase leverage for the organization. This involves working closely with the members of our three Science Institutes.
• Design and build the organization and resources required for non-clinical studies and filings at Altos ensuring the right capacity, infrastructure, business model, and novel competencies to deliver on our emerging pipeline
• Drive a streamlined operating model aligned with stakeholder needs and cross-functional processes, with an emphasis on clear decision-making, communication, prioritization, and resource allocation
• Lead and shape a Non Clinical Leadership Team, to be comprised of top industry talent (with deep scientific expertise within their functions) as well as required partnerships and CROs. Serve as key member of cross-functional leadership teams
• Represent non-clinical development during interactions/presentations with regulatory agencies
• Selection of partners and study protocol design and oversight of conduct for proof-of-concept, pilot, and pivotal/IND-enabling studies
• Ensure alignment of nonclinical activities with clinical development, drug manufacturing, and regulatory plans
• Build a team culture that promotes continuous improvement, ownership, professional growth, and inclusion
• Manage budgets and hiring plans for your teams

Who You Are

Minimum Qualifications

• MD, PhD or MD/PhD with at least 15 years of post-training experience in academia, biotech or pharma. Industry experience in drug discovery and development required
• Excited about identifying and meeting the challenges inherent in bringing drugs with novel mechanisms of action into the clinic
• Experienced in multiple indication types and addressing regulatory requirements internationally
• Experience with multiple drug modalities including small molecules, biologics, nucleic acid-based drugs, and the utilization of drug delivery approaches
• Familiar with the use of genetics and 'omics platforms and the applications of machine learning in drug discovery and clinical trial design
• Proven capability to lead, motivate and inspire in a diverse, global, cross-functional structure and commit to diversity, equity and belonging. A strong record of developing and mentoring excellent leaders
• A critical thinker with the ability to analyze possibilities and solutions and make pragmatic trade-offs, as well as a big picture innovator who can identify possibilities and is comfortable with ambiguity
• Clear and influential communicator: exceptional influencing skills that demonstrate strong thought partnership and create effective relationships with internal and external stakeholders
• Excellent collaboration skills and ability to build and connect strong teams and build community across Altos

Preferred Qualifications

• Experience working with academic and governmental organizations in clinical trial design to include experimental medicine and academically sponsored clinical trials
• Expertise in the molecular biology of transcription factors
• Broad experience in the diseases associated with aging

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